Coupling of Methyl Ketones and Primary or Secondary Amines Leading to α-Ketoamides
The Journal of Organic Chemistry2012Vol. 77(17), pp. 7157–7165
Citations Over TimeTop 10% of 2012 papers
Abstract
A metal-free oxidative coupling of methyl ketones and primary or secondary amines to α-ketoamides has been developed. Four intermediates, α-iodoketone, α-aminoketone, iminium intermediate, and α-hydroxy amine have been identified through a series of control experiments. The atom-economic methodology can be scaled-up, tolerates a variety of functional groups, and is operationally simple.
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