Palladium-Catalyzed Direct ortho-Acylation through an Oxidative Coupling of Acetanilides with Toluene Derivatives
The Journal of Organic Chemistry2012Vol. 77(24), pp. 11339–11344
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Abstract
A facile ortho-acylation of acetanilides by a Pd-catalyzed oxidative C-H activation was developed in which low toxic, stable, and commercially available toluene derivatives were first used as acylation reagents by a tandem reaction to form o-acylacetanilides with moderate to good yields. Inexpensive, safe, and environmentally benign TBHP was proved to be an effective oxidant for these transformations.
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