Natural α-Amino Acids Applied in the Synthesis of Imidazo[1,5-a]N-heterocycles under Mild Conditions
The Journal of Organic Chemistry2012Vol. 77(24), pp. 11161–11166
Citations Over TimeTop 12% of 2012 papers
Abstract
A facile iodine-mediated decarboxylative cyclization from α-amino acids and N-heterocyclic carbaldehydes was developed. By virtue of this method, a series of imidazo[1,5-a]N-heterocycles can be synthesized efficiently under mild conditions. A tentative reaction mechanism was proposed based on the experimental results and previous reports.
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