Isolation of an σ-Alkyl Iridium Hydride Complex, Formed in the (Semi)hydrogenation of an β-Enamido Ketone
The Journal of Organic Chemistry2013Vol. 78(7), pp. 3425–3428
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Abstract
σ-Alkyl iridium hydride complexes are generally postulated as intermediates in iridium-catalyzed hydrogenation. Fast reductive elimination results in the formation of the hydrogenation product. With an β-enamido ketone as unsaturated substrate, such an intermediate could be trapped because the semihydrogenated product coordinates trifold to the iridium, generating a stable 18e(-) complex, which does not eliminate.
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