Ligand-Dependent Site-Selective Suzuki Cross-Coupling of 3,5-Dichloropyridazines
The Journal of Organic Chemistry2013Vol. 78(15), pp. 7758–7763
Citations Over TimeTop 14% of 2013 papers
Xing Dai, Yonggang Chen, Stephanie Garrell, Hong Liu, Li‐Kang Zhang, Anandan Palani, Gregory Hughes, Ravi P. Nargund
Abstract
General methods for the highly site-selective Suzuki monocoupling of 3,5-dichloropyridazines have been discovered. By changing the ligand employed, the preferred coupling site can be switched from the 3-position to the 5-position, typically considered the less reactive C-X bond. These conditions are applicable to the coupling of a wide variety of aryl-, heteroaryl-, and vinylboronic acids with high selectivities, thus enabling the rapid construction of diverse arrays of diarylpyradazines in a modular fashion.
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