Conformationally Assisted Lactamizations for the Synthesis of Symmetrical and Unsymmetrical Bis-2,5-diketopiperazines
The Journal of Organic Chemistry2013Vol. 78(17), pp. 8510–8523
Citations Over TimeTop 23% of 2013 papers
Khanh Ha, Iryna Lebedyeva, Zhiliang Li, Kristin Martin, Byron C. Williams, Eric Faby, Amir Nasajpour, Girinath G. Pillai, Abdulrahman O. Al‐Youbi, Alan R. Katritzky
Abstract
Open-chain N-Cbz-protected-peptidoyl benzotriazolides are converted by a novel lactamization strategy using proline as a turn introducer into both symmetrical (5a-c and 11a-c) and unsymmetrical (19a-e) bis-2,5-diketopiperazines (bis-2,5-DKPs), previously recognized as difficult targets.
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