Angucycline C5 Glycosides: Regio- and Stereocontrolled Synthesis and Cytotoxicity
The Journal of Organic Chemistry2013Vol. 78(19), pp. 9748–9757
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Abstract
This study discloses a general and convergent route for the regio- and stereospecific construction of the C5 glycosyl angucycline framework of mayamycin. C-Glycosidation, dearomatization, and Hauser annulation are the key steps. The synthetic analogues show cytotoxicity against different human cancer cell lines with IC50 values between 16.4 and 1.2 μM.
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