Three-Component Cascade Annulation of β-Ketothioamides Promoted by CF3CH2OH: A Regioselective Synthesis of Tetrasubstituted Thiophenes
The Journal of Organic Chemistry2013Vol. 78(21), pp. 10617–10628
Citations Over TimeTop 10% of 2013 papers
Abstract
A rapid and highly efficient method for the regioselective synthesis of thiophene derivatives has been developed by annulation of β-ketothioamides with arylglyoxals and 5,5-dimethyl-1,3-cyclohexanedione in CF3CH2OH within 15 min. The present synthesis has several desirable features, such as high regioselectivity, a concise one-pot protocol, short reaction time, and easy purification. This methodology provides an alternative approach for easy access to tetrasubstituted thiophenes via a one-pot cascade reaction without other additives.
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