2-Aminopyridines via Reaction of Pyridine N-Oxides and Activated Isocyanides
The Journal of Organic Chemistry2014Vol. 79(5), pp. 2274–2280
Citations Over TimeTop 12% of 2014 papers
Abstract
A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.
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