Regioselective Hydration of Terminal Halo-Substituted Propargyl Carboxylates by Gold Catalyst: Synthesis of α-Acyloxy α′-Halo Ketones
The Journal of Organic Chemistry2014Vol. 79(6), pp. 2453–2462
Citations Over TimeTop 10% of 2014 papers
Abstract
Regioselective hydration of the terminal halo-substituted propargyl carboxylate by gold(I) catalyst is reported. The mild catalytic conditions tolerate common acid-labile protecting groups, and a wide variety of α-acyloxy α'-halo ketones are efficiently synthesized within a short reaction time. The α-acyloxy α'-halo ketones are used for the synthesis of 2-aminothiazoles.
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