Enantioselective Desymmetrization of Diesters
The Journal of Organic Chemistry2014Vol. 79(5), pp. 2303–2307
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Abstract
The desymmetrization of prochiral diesters with a chiral phosphoric acid catalyst to produce highly enantioenriched lactones in excellent yield is reported. The process is easily scaled and accommodates a variety of substitution patterns, many of which result in the generation of an enantioenriched all-carbon quaternary center. Manipulation of lactone product to useful small building blocks is also described.
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