Total Synthesis of Streptonigrone
The Journal of Organic Chemistry2007Vol. 72(22), pp. 8489–8495
Citations Over TimeTop 10% of 2007 papers
Abstract
A total synthesis of streptonigrone, 1, is described, which incorporates a one-step synthesis of substituted pyridones devised in our laboratory. Other aspects of the synthesis that differentiate the present approach from previous ones are the use of a Conrad-Limpach reaction, rather than the customary Friedländer methodology, to assemble the quinoline segment of 1, and the implementation of an anionic sequence for the functionalization of a key pyridone intermediate.
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