Fluorous-Tagged Carbamates for the Pd-Catalyzed Amination of Aryl Halides
The Journal of Organic Chemistry2007Vol. 72(21), pp. 8146–8148
Citations Over TimeTop 11% of 2007 papers
Abstract
A novel fluorous-tagged ammonia surrogate has been synthesized and its application to the synthesis of anilines by Buchwald-Hartwig palladium-catalyzed amidation-hydrolysis protocol is described. Primary anilines were obtained in moderate to good yields after a sequence of two reaction steps involving fluorous separation techniques for their purification. Preliminary results indicate that N-substituted anilines can also be obtained using just N-substituted-FBoc carbamates as the nitrogen source.
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