A Total Synthesis of OSW-1
The Journal of Organic Chemistry2007Vol. 73(1), pp. 157–161
Citations Over TimeTop 20% of 2007 papers
Abstract
A new and practical method was developed to synthesize OSW-1, a natural saponin with potent antitumor activities, from (+)-dehydroisoandrosterone, l-arabinose, and D-xylose on gram scale. The synthesis was achieved in 10 linear steps with an overall yield of 6.4% starting from (+)-dehydroisoandrosterone.
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