Direct Ortho-Acetoxylation of Anilides via Palladium-Catalyzed sp2 C−H Bond Oxidative Activation
The Journal of Organic Chemistry2008Vol. 73(12), pp. 4717–4720
Citations Over TimeTop 10% of 2008 papers
Abstract
Various anilides have been directly ortho-acetoxylated through a Pd(OAc)2-catalyzed C-H bond activation process. The amide group in anilides was found to functionalize as an elegant directing group to convert aromatic sp(2) C-H bonds into C-O bonds in high regioselectivity with acetic acid as the acetate source and K(2)S(2)O(8) as the oxidant.
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