Organocatalytic Enantioselective Michael Addition of 2,4-Pentandione to Nitroalkenes Promoted by Bifunctional Thioureas with Central and Axial Chiral Elements
The Journal of Organic Chemistry2008Vol. 73(13), pp. 5202–5205
Citations Over TimeTop 10% of 2008 papers
Abstract
Two novel bifunctional amine-thiourea organocatalysts 1 and 2, which both bear central and axial chiral elements, have been developed to promote enantioselective Michael reaction between 1,3-dicarbonyl compounds and nitro olefins. The catalyst 2 afforded the desired products with good levels of enantioselectivity (up to 96% ee), showing clearly that two chiral elements of 2 are matched, and enhance the stereochemical control.
Related Papers
- → Antiviral Activity of Thiazole-thiourea Derivatives(1967)4 cited
- Electrochemical behaviors of thiourea in alkaline medium(2008)
- → Tensammetric studies of thiourea and its derivatives(1961)1 cited
- Synthesis of Thiourea and its Derivatives(2011)
- Mechanism of gold dissolving in alkaline thiourea solution(2007)