Highly Efficient and Highly Enantioselective Asymmetric Hydrogenation of Ketones with TunesPhos/1,2-Diamine−Ruthenium(II) Complexes
The Journal of Organic Chemistry2008Vol. 74(3), pp. 1397–1399
Citations Over TimeTop 11% of 2008 papers
Abstract
The TunePhos/diamine-Ru(II) complex combined with t-BuOK in 2-propanol effectively catalyzes enantioselective hydrogenation of a wide range of simple ketones including aromatic, heteroaromatic, alpha,beta-unsaturated, and cyclopropyl ketones, affording high reactivity (up to 1,000,000 TON) and excellent enantioselectivities (>99% ee for 13 examples).
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