En Route to (S)-Selective Chemoenzymatic Dynamic Kinetic Resolution of Aliphatic Amines. One-Pot KR/Racemization/KR Sequence Leading to (S)-Amides
The Journal of Organic Chemistry2009Vol. 74(7), pp. 2901–2903
Citations Over TimeTop 10% of 2009 papers
Lahssen El Blidi, Malek Nechab, Nicolas Vanthuyne, Stéphane Gastaldi, Michèle P. Bertrand, Gérard Gil
Abstract
A one-pot sequential process, involving a radical racemization and an enzymatic resolution, provides access to (S)-amides, from racemic amines, with ee and yields ranging from 78 to 94% and 58 to 80%, respectively.
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