Synthesis of Hyaluronic Acid Oligomers using Chemoselective and One-Pot Strategies
The Journal of Organic Chemistry2009Vol. 74(11), pp. 4208–4216
Citations Over TimeTop 11% of 2009 papers
Abstract
An efficient synthetic strategy toward a hyaluronic acid (HA) tri-, penta-, and heptamer having a glucosamine-reducing end is reported. The synthesis is based on a glucuronate ester thioglycoside and a trifluoro-N-phenylimidate glucosamine building block. The HA-fragments are synthesized using an S-phenyl GlcN-GluA building block through a combination of chemoselective and one-pot condensation strategies.
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