Concise Total Synthesis of (+)-Aspergillide B
The Journal of Organic Chemistry2009Vol. 74(14), pp. 5063–5066
Citations Over TimeTop 10% of 2009 papers
Abstract
An efficient total synthesis of (+)-aspergillide B has been achieved, which features the C-glycosylation reaction for constructing the 2,6-trans-substituted pyran core, a highly effective four-step sequence without purification to produce the key intermediate 13 and an advantegous E-selective Julia-Kocienski olefination on a highly elaborate substrate. The synthesis confirmed the revised structure of aspergillide B by Uenishi.
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