Organocatalytic Highly Enantio- and Diastereoselective Mannich Reaction of β-Ketoesters with N-Boc-aldimines
The Journal of Organic Chemistry2009Vol. 74(15), pp. 5734–5737
Citations Over TimeTop 10% of 2009 papers
Abstract
The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of beta-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-amino beta-ketoesters with excellent diastereoselectivities (up to 100:0 dr) and excellent enantioselectivities (up to 99% ee).
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