Sequential Five-Component Synthesis of Spiropyrrolidinochromanones
The Journal of Organic Chemistry2009Vol. 74(17), pp. 6888–6890
Citations Over TimeTop 10% of 2009 papers
Abstract
Herein we report a novel, diastereoselective, one-pot, two-step, sequential synthesis of highly functionalized natural product-like spiropyrrolidinochromanones. The process consists of an Ugi four-component condensation of 3-formylchromones with amines, isocyanides, and glyoxylic acids followed by a nucleophilic conjugate addition and intramolecular cyclization. The experimental simplicity and tolerance to a wide variety of substituents makes this method suitable for combinatorial synthesis.
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