Semisynthetic Derivatives of Sesquiterpene Lactones by Palladium-Catalyzed Arylation of the α-Methylene-γ-lactone Substructure
The Journal of Organic Chemistry2009Vol. 74(18), pp. 7176–7179
Citations Over TimeTop 17% of 2009 papers
Abstract
The palladium-catalyzed arylation of different α-methylene-γ-lactone-containing sesquiterpene lactones was shown to produce E-olefin coupling products selectively in moderate to excellent yields. Biological evaluation of these semisynthetic sesquiterpene lactone derivatives in HeLa cells showed interesting antiproliferative profiles and provided initial structure−activity data.
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