Aberrarone: A Gorgonian-Derived Diterpene from Pseudopterogorgia elisabethae
The Journal of Organic Chemistry2009Vol. 74(19), pp. 7581–7584
Citations Over TimeTop 11% of 2009 papers
Abstract
A marine metabolite based on a previously undescribed carbon skeleton, aberrarone (1), is reported as a natural product from the Caribbean sea whip, Pseudopterogorgia elisabethae. The molecular structure of the crystalline metabolite was established by spectral analysis and subsequently confirmed by X-ray crystallographic analysis. Aberrarone shows in vitro antimalarial activity against a chloroquine-resistant strain of the protozoan parasite Plasmodium falciparum.
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