A Practical Synthesis ofm-Prostaglandin E Synthase-1 Inhibitor MK-7285
The Journal of Organic Chemistry2009Vol. 74(20), pp. 7790–7797
Citations Over TimeTop 23% of 2009 papers
Abstract
A practical, kilogram-scale chromatography-free synthesis of mPGE synthase I inhibitor MK-7285 is described. The route features a convergent assembly of the core phenanthrene unit via amide-directed ortho-metalation and proximity-induced anionic cyclization, followed by imidazole synthesis and late-stage cyanation.
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