Synthesis of an Unlocked Nucleic Acid Terpyridine Monomer and Binding of Divalent Metal Ion in Nucleic Acid Duplexes
The Journal of Organic Chemistry2009Vol. 74(22), pp. 8838–8841
Citations Over TimeTop 23% of 2009 papers
Abstract
Herein we present the synthesis and thermal stability studies of modified oligonucleotides containing an unlocked nucleic acid (UNA) terpyridine monomer. Incorporation of this monomer into both strands of a DNA duplex allowed reversible thermal stability modulation upon addition or withdrawal of divalent metal ions. A likely explanation of this phenomenon is interstrand complexation between two terpyridine units and a metal ion. This system could be useful in the development of nanoscale devices based on DNA hybridization.
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