Triethanolamine-Mediated Palladium-Catalyzed Regioselective C-2 Direct Arylation of Free NH-Pyrroles
The Journal of Organic Chemistry2010Vol. 75(9), pp. 3109–3112
Citations Over TimeTop 10% of 2010 papers
Abstract
An atom-economical phosphane-free palladium-catalyzed direct C-2 arylation of unactivated free NH-pyrroles is devised. This method provides a straightforward route to a wide variety of substituted 2-aryl-1H-pyrroles from readily accessible starting materials. Iodoarenes bearing electron-withdrawing and electron-donating substituents are tolerated under the presented reaction conditions. The scope of the reaction is also expanded to N-aryl and -alkylpyrroles albeit in lower yields.
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