Practical Route to a New Class of LTD4 Receptor Antagonists
The Journal of Organic Chemistry1996Vol. 61(10), pp. 3398–3405
Citations Over TimeTop 21% of 1996 papers
Robert D. Larsen, Edward G. Corley, Anthony O. King, James D. Carroll, Paul Davis, Thomas R. Verhoeven, Paul J. Reider, Marc Labelle, Jacques Yves Gauthier, Yi Xiang, Robert Zamboni
Abstract
A general approach to the synthesis of a new class of LTD4 antagonists is presented. The key diarylpropane framework was prepared by Claisen−Schmidt condensation and selective reduction of the enone. Depending on the bridge to the 7-chloroquinaldine moiety, alkylation or Heck coupling methodology was developed. The chiral sulfides were introduced by asymmetric reduction of the diarylpropanone intermediates and subsequent inversion of the chiral center.
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