Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones

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ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTAsymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinonesPher G. Andersson, Hans E. Schink, and Krister ÖsterlundView Author Information Department of Organic Chemistry, University of Uppsala, Box 531, S-751 21, Uppsala, Sweden, and Department of Chemistry, Pharmacia & Upjohn, S-751 82, Uppsala, Sweden Cite this: J. Org. Chem. 1998, 63, 22, 8067–8070Publication Date (Web):October 16, 1998Publication History Received29 June 1998Published online16 October 1998Published inissue 1 October 1998https://pubs.acs.org/doi/10.1021/jo981259rhttps://doi.org/10.1021/jo981259rbrief-reportACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views1116Altmetric-Citations72LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Anions,Conjugate acid-base pairs,Enantioselective synthesis,Reagents,Substitution reactions Get e-Alerts

Asymmetric Total Synthesis of (+)-Tolterodine, a New Muscarinic Receptor Antagonist, via Copper-Assisted Asymmetric Conjugate Addition of Aryl Grignard Reagents to 3-Phenyl-prop-2-enoyl-oxazolidinones

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