A Highly Enantioselective Benzothiepine Synthesis
The Journal of Organic Chemistry2000Vol. 65(9), pp. 2711–2715
Citations Over TimeTop 10% of 2000 papers
Abstract
A highly enantioselective synthesis of benzothiepine 1a has been accomplished via an enantioenriched sulfoxide intermediate obtained by asymmetric oxidation with a chiral oxaziridine in 89:11 er. The key step is a thermodynamically controlled asymmetric cyclization reaction that produces two new stereogenic centers. The (4R,5R) isomer 1a was obtained in 98:2 er.
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