Calcium Carbonate/Carboxymethyl Chitosan Hybrid Microspheres and Nanospheres for Drug Delivery

Citations Over TimeTop 10% of 2010 papers

Abstract

Calcium carbonate/carboxymethyl chitosan (CaCO3/CMC) hybrid microspheres and nanospheres were prepared by the precipitation of calcium carbonate in an aqueous solution containing CMC. Through adjusting the preparation conditions, the size of CaCO3/CMC hybrid particles could be easily controlled at micro- to nanometer ranges with relatively narrow size distributions. The obtained microspheres and nanospheres were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The size and size distribution were measured by a particle size analyzer. Doxorubicin hydrochloride (DOX·HCl), a water-soluble anticancer drug, was loaded in the hybrid microspheres and nanospheres with a high encapsulation efficiency. The in vitro drug release showed that the release of DOX·HCl from the microspheres and nanospheres could be effectively sustained.

Related Papers

• → The thermogravimetric analysis of some polysiloxanes(1998)186 cited
• → The use of thermogravimetric analysis technique for the characterization of construction materials(2008)77 cited
• → Kinetic analysis of thermogravimetric data on some nickel(II) N-alkyldithiocarbamates(1989)25 cited
• → Thermogravimetric analysis for the characterization and comparative analysis of polyvinyl chloride (PVC) wall panel(2023)1 cited
• Thermogravimetric analysis of fuel film evaporation(2006)