Use of immobilized artificial membrane chromatography for drug transport applications††Abbreviations: blood-brain barrier, BBB; bovine brain microvessel endothelial cells, BBMEC; calculated log distribution coefficient (Pallas, CompuDrug, Budapest, Hungary), ClogD; calculated log partition coefficient, ClogP; capacity factor on an IAM column, k¢IAM; capacity factor on a reversed-phase column, k¢w; log distribution coefficient, log D; immobilized artificial membrane, IAM; nonsteroidal antiinflammatory, NSAID; octadecylsilicate, ODS; log octanol:water intrinsic partition coefficient, log P; phosphate-buffered saline, PBS; phosphatidylcholine, PC.
Journal of Pharmaceutical Sciences1998Vol. 87(12), pp. 1471–1478
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