Gold Nanoparticle Decoration of DNA on Silicon
Langmuir2005Vol. 21(23), pp. 10699–10701
Citations Over TimeTop 11% of 2005 papers
Gary B. Braun, Katsuhiko Inagaki, R. August Estabrook, David K. Wood, Eran Levy, A. N. Cleland, Geoffrey F. Strouse, Norbert O. Reich
Abstract
Electrostatic assembly of cationic nanoparticles onto the negatively charged backbone of double-stranded DNA has been shown to produce one-dimensional chains with potential use as nanoelectronic components. In this paper, micron long DNA templates stretched on aminosilane- and hexamethyldisilazane-modified silicon surfaces are used to assemble 3.5 nm gold nanoparticles passivated with cationic thiocholine. Atomic force microscopy is used to analyze the density and defects along the approximately 5 nm high structures, with comparison between positively charged and neutral surfaces. Low background adsorption of nanoparticles is facilitated by both these surface chemistries, while the neutral surface yields a more densely packed assembly.
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