Gold Nanoparticles as Carriers for Efficient Transmucosal Insulin Delivery
Citations Over TimeTop 10% of 2005 papers
Abstract
Nanomaterials have gained tremendous importance in biology and medicine because they can be used as carriers for delivering small molecules such as drugs, proteins, and genes. We report herein the binding of the hormone insulin to gold nanoparticles and its application in transmucosal delivery for the therapeutic treatment of diabetes mellitus. Insulin was loaded onto bare gold nanoparticles and aspartic acid-capped gold nanoparticles and delivered in diabetic Wistar rats by both oral and intranasal (transmucosal) routes. Our principle observations are that there is a significant reduction of blood glucose levels (postprandial hyperglycemia) when insulin is delivered using gold nanoparticles as carriers by the transmucosal route in diabetic rats. Furthermore, control of postprandial hyperglycemia by the intranasal delivery protocol is comparable to that achieved using the standard subcutaneous administration used for type I diabetes mellitus, thus showing considerable promise for further development.
Related Papers
- → Novel aspects of postprandial lipemia in relation to atherosclerosis(2008)93 cited
- → Determinant of postprandial triglyceride levels in healthy young adults(2019)9 cited
- → Update on postprandial hyperglycemia: The pathophysiology, prevalence, consequences and implications of treating diabetes(2018)11 cited
- Correlation research of the elderly postprandial hypotension and vascular endothelial function(2012)
- [Postprandial hyperglycemia].(2003)