Glucose-Responsive Polyelectrolyte Capsules

Citations Over TimeTop 10% of 2006 papers

Abstract

Phenylboronic acids are known to form covalent complexes with polyol compounds such as glucose. A novel polyelectrolyte, containing phenylboronic acid as a glucose-sensitive moiety, has been synthesized and used for the fabrication of glucose-sensitive hollow polyelectrolyte capsules using the layer-by-layer technique. The response to glucose was observed as a rather fast dissolution of the capsules when brought into contact with a glucose-containing medium. These polyelectrolyte capsules are the first polyelectrolyte capsules able to respond to a stimulus that can be provided by the human body (i.e., an increase in glucose concentration). Therefore, the concept we present has promising applications in the biomedical field for the controlled delivery of insulin.

Related Papers

• → A totally synthetic glucose responsive gel operating in physiological aqueous conditions(2010)151 cited
• → Synthesis of hydrogel-bearing phenylboronic acid moieties and their applications in glucose sensing and insulin delivery(2018)88 cited
• → Physical properties of a soy-based polyol as polyurethane coatings(2018)5 cited
• → Novel Carbamylmethylated Melamine Polyols in Rigid Water-Blown Urethane Foams(1992)1 cited
• → Monosaccharides Sensing Characteristics of Phenylboronic Acid Monolayers(2002)