Surfaces of Fluorinated Pyridinium Block Copolymers with Enhanced Antibacterial Activity
Langmuir2006Vol. 22(26), pp. 11255–11266
Citations Over TimeTop 10% of 2006 papers
Sitaraman Krishnan, Rebekah J. Ward, Alexander Hexemer, Karen E. Sohn, Kristen L. Lee, Esther R. Angert, Daniel A. Fischer, Edward J. Krämer, Christopher K. Ober
Abstract
Polystyrene-b-poly(4-vinylpyridine) copolymers were quaternized with 1-bromohexane and 6-perfluorooctyl-1-bromohexane. Surfaces prepared from these polymers were characterized by contact angle measurements, near-edge X-ray absorption fine structure spectroscopy and X-ray photoelectron spectroscopy. The fluorinated pyridinium surfaces showed enhanced antibacterial activity compared to their nonfluorinated counterparts. Even a polymer with a relatively low molecular weight pyridinium block showed high antimicrobial activity. The bactericidal effect was found to be related to the molecular composition and organization in the top 2-3 nm of the surface and increased with increasing hydrophilicity and pyridinium concentration of the surface.
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