Self-Assembly of Palmitoyl Lipopeptides Used in Skin Care Products
Citations Over TimeTop 18% of 2013 papers
Abstract
The self-assembly of three cosmetically active peptide amphiphiles C16-GHK, C16-KT, and C16-KTTKS (C16 denotes a hexadecyl, palmitoyl chain) used in commercial skin care products is examined. A range of spectroscopic, microscopic, and X-ray scattering methods is used to probe the secondary structure, aggregate morphology, and the nanostructure. Peptide amphiphile (PA) C16-KTTKS forms flat tapes and extended fibrillar structures with high β-sheet content. In contrast, C16-KT and C16-GHK exhibit crystal-like aggregates with, in the case of the latter PA, lower β-sheet content. All three PA samples show spacings from bilayer structures in small-angle X-ray scattering profiles, and all three have similar critical aggregation concentrations, this being governed by the lipid chain length. However, only C16-KTTKS is stained by Congo red, a diagnostic dye used to detect amyloid formation, and this PA also shows a highly aligned cross-β X-ray diffraction pattern consistent with the high β-sheet content in the self-assembled aggregates. These findings may provide important insights relevant to the role of self-assembled aggregates on the reported collagen-stimulating properties of these PAs.
Related Papers
- → Supramolecular Interactions and Morphology of Self-Assembling Peptide Amphiphile Nanostructures(2021)62 cited
- → Sequence length determinants for self‐assembly of amphipathic β‐sheet peptides(2013)42 cited
- → Tuning One‐Dimensional Nanostructures of Bola‐Like Peptide Amphiphiles by Varying the Hydrophilic Amino Acids(2016)37 cited
- → Design, Synthesis, and Characterization of Self-assembled Peptide Nanostructures toward Peptide-directed Biomineralization(2011)8 cited