Histidine-Derived Nontoxic Nitrogen-Doped Carbon Dots for Sensing and Bioimaging Applications
Langmuir2014Vol. 30(45), pp. 13542–13548
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He Huang, Chun Guang Li, Shoujun Zhu, Hailong Wang, Cailing Chen, Zhaorui Wang, Tianyu Bai, Zhan Shi, Shouhua Feng
Abstract
Nitrogen-doped (N-doped) photoluminescent carbon dots (CDs) were prepared by a one-pot microwave-assisted hydrothermal treatment using histidine as the sole carbon source in the absence of acid, alkali, or metal ions. With a diameter of 2-5 nm, the synthesized CDs had apparent lattice fringes and exhibited an excitation-dependent photoluminescent behavior. The CDs were highly yielded, well-dispersed in aqueous solution, and showed high photostability in the solutions of a wide range of pH and salinity. They were used as probes to identify the presence of Fe(3+) ions with a detection limit of 10 nM. With confirmed nontoxicity, these CDs could enter the cancer cells, indicating a practical potential for cellular imaging and labeling.
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