Identification of a Series of Compounds with Potent Antiviral Activity for the Treatment of Enterovirus Infections
ACS Medicinal Chemistry Letters2013Vol. 4(7), pp. 585–589
Citations Over TimeTop 10% of 2013 papers
Angus M. MacLeod, Dale R. Mitchell, Nicholas J. Palmer, Hervé Van de Poël, Katja Conrath, Martin Andrews, Pieter Leyssen, Johan Neyts
Abstract
Rhinovirus (genus enterovirus) infections are responsible for many of the severe exacerbations of asthma and chronic obstructive pulmonary disease. Other members of the genus can cause life-threatening acute neurological infections. There is currently no antiviral drug approved for the treatment of such infections. We have identified a series of potent, broad-spectrum antiviral compounds that inhibit the replication of the human rhinovirus, Coxsackie virus, poliovirus, and enterovirus-71. The mechanism of action of the compounds has been established as inhibition of a lipid kinase, PI4KIIIβ. Inhibition of hepatitis C replication in a replicon assay correlated with enterovirus inhibition.
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