Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives
ACS Medicinal Chemistry Letters2014Vol. 5(6), pp. 657–661
Citations Over TimeTop 10% of 2014 papers
María J. Chaparro, Jaume Vidal, Íñigo Angulo‐Barturen, José M. Bueno, Jeremy N. Burrows, N. Cammack, Pablo Castañeda, Gonzalo Colmenarejo, José M. Coterón, Laura de las Heras, Esther Fernández, Santiago Ferrer, Raquel Gabarró, Francisco‐Javier Gamo, Mercedes García, Marı́a Belén Jiménez-Dı́az, María José Lafuente, María Luisa León, Maria Santos Martínez, Douglas J. Minick, Sara Prats, Margarita Puente, Lourdes Rueda, Elena Sandoval, Ángel Santos-Villarejo, Michael J. Witty, Félix Calderón
Abstract
Antiparasitic oral drugs have been associated to lipophilic molecules due to their intrinsic permeability. However, these kind of molecules are associated to numerous adverse effects, which have been extensively studied. Within the Tres Cantos Antimalarial Set (TCAMS) we have identified two small, soluble and simple hits that even presenting antiplasmodial activities in the range of 0.4-0.5 μM are able to show in vivo activity.
Related Papers
- → A comparison of in vivo and in vitro methods for determining availability of iron from meals(1981)109 cited
- → Structure determination of LL-F28249α, β, γ, and λ, potent antiparasitic macrolides from Streptomyces cyaneogriseus ssp. noncyanogenus(1987)41 cited
- → Alkaline oxidization can increase the in vitro antiparasitic activity of proanthocyanidin-rich plant extracts against Ascaris suum(2023)3 cited
- → In vivo analysis of skin microcirculation in rats and mice(2008)2 cited
- → In Vivo Electroporation: A Convenient Method for Gene Transfer to Testicular Cells in Mice(1996)17 cited