Synthesis and Characterization of a “Turn-On” photoCORM for Trackable CO Delivery to Biological Targets
ACS Medicinal Chemistry Letters2014Vol. 5(12), pp. 1324–1328
Citations Over TimeTop 10% of 2014 papers
Abstract
A designed photoactive CO releasing molecule (photoCORM), namely, fac-[MnBr(CO)3(pbt)] (1, pbt = 2-(2-pyridyl)benzothiazole), promotes CO-induced death of MDA-MB-231 human breast cancer cells upon illumination with broadband visible light. The CO release from this photoCORM can be tracked by rise in fluorescence within the cellular matrix due to deligation of the pbt ligand. The results of this study suggest the potential of 1 in eradication of cancer cells through CO delivery.
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