Potent Irreversible Inhibitors of LasR Quorum Sensing in Pseudomonas aeruginosa
ACS Medicinal Chemistry Letters2014Vol. 6(2), pp. 162–167
Citations Over TimeTop 13% of 2014 papers
Abstract
Antagonism of quorum sensing represents a promising new antivirulence approach for the treatment of bacterial infection. The development of a novel series of non-natural irreversible antagonists of P. aeruginosa LasR is described. The lead compounds identified (25 and 28) display potent LasR antagonist activity and inhibit expression of the P. aeruginosa virulence factors pyocyanin and biofilm formation in PAO1 and PA14.
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