Toward the Next-Generation Drug Delivery Vehicle: Synthesis of a Dendrimer with Four Orthogonally Reactive Groups
Molecular Pharmaceutics2005Vol. 2(4), pp. 273–277
Citations Over TimeTop 10% of 2005 papers
Abstract
The synthesis of a dendrimer based on melamine that displays multiple copies of four orthogonally reactive groups, three on the surface and one on the interior, is described. The three groups on the surface are nucleophilic and include four free hydroxyl groups, four hydroxyl groups masked as tert-butyldiphenylsilyl (TBDPS) ethers, and 16 amines masked as tert-butoxycarbonyl (BOC) groups. The core of the dendrimer displays two electrophilic monochlorotriazines. The dendrimer is available in seven linear steps (eight total steps) at 55% overall yield for the longest linear sequence.
Related Papers
- → The dendritic effect illustrated with phosphorus dendrimers(2014)129 cited
- Dendrimers in medicine and biotechnology. New molecular tools(2006)
- → Force Biased Molecular Dynamics Simulation Study of Effect of Dendrimer Generation on Interaction with DNA(2012)25 cited
- → An alternative convergent synthesis of dendrimers with 2,5-diarylsilole at the core(2007)17 cited
- → Syntheses of Dendrimers and Dendrons(2011)6 cited