Supramolecular Fluorescent Nanoparticles for Targeted Cancer Imaging
Citations Over TimeTop 13% of 2012 papers
Abstract
By a combination of excellent fluorescent performance with smart targeting capability for cancer-specific delivery, a promising class of calcein-based supramolecular fluorescent nanoparticles has been successfully prepared via a "bricks and mortar" strategy. Through tuning the molar ratio of adamantane-functionalized calcein (CA-AD)/β-cyclodextrin-grafted branched polyethylenimine (PEI-CD), the size of these fluorescent nanoparticles can be effectively controlled. Importantly, the β-cyclodextrin/adamantane (β-CD/AD = 1/1) host-guest interaction dramatically suppresses the π-π stacking and fluorescence self-quenching of calcein chromophores in water, leading to the formation of highly fluorescent nanoparticles. By introduction of the folate receptor, these fluorescent nanoparticles exhibit excellent cancer imaging efficiency.
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