Collagen Coating Promotes Biocompatibility of Semiconductor Nanoparticles in Stratified LBL Films
Nano Letters2003Vol. 3(9), pp. 1177–1182
Citations Over TimeTop 10% of 2003 papers
Vladimir A. Sinani, Dmitry S. Koktysh, Bo-Geon Yun, Robert L. Matts, Todd C. Pappas, Massoud Motamedi, Stephanie N. Thomas, Nicholas A. Kotov
Abstract
Nanostructured thin films fabricated from semiconductor nanoparticles (NPs) are of great interest for biomedical applications, but NP materials based on heavy metals can be cytotoxic. In this work, the preparation of semiconductor NPs followed the protocol of layer-by-layer (LBL) assembly, which alleviates this problem. Collagen/poly(acrylic acid) bilayers were added to CdTe/polycation LBL films to produce porous collagen bilayers. Such stratified multilayer systems showed successful cell attachment and survival while native NP films were strongly cytotoxic.
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