Preparation of Nucleic Acid Functionalized Carbon Nanotube Arrays

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Abstract

A vertically aligned carbon nanotube (CNT) array is fabricated as a nanoelectrode platform for biosensor development. Prior to chemical functionalization, metal catalyst particles at the ends of CNT are removed and the closed ends are opened. We find that the oxidative treatment for generating the chemical functional groups at the opened ends of the CNT compromise the mechanical stability of the nanotubes, often leading to total collapse of the aligned CNTs. To solve this problem, we have developed a new approach for filling the gaps between CNTs with a spin-on glass (SOG). Results from the coupling of nucleic acids to the CNT arrays suggest that the SOG enhances the reactivity by providing structural support to the CNTs. The SOG also covers the length of the sidewalls of CNTs, leading to a less hydrophobic interface and thus may aid in improving the chemical reactivity.

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