Biomolecular Recognition Based on Single Gold Nanoparticle Light Scattering
Nano Letters2003Vol. 3(7), pp. 935–938
Citations Over TimeTop 1% of 2003 papers
G. Raschke, Stefan Kowarik, T. Franzl, Carsten Sönnichsen, Thomas A. Klar, Jochen Feldmann, Alfons Nichtl, K. Kürzinger
Abstract
A method for biomolecular recognition is reported using light scattering of a single gold nanoparticle functionalized with biotin. Addition of streptavidin and subsequent specific binding events alter the dielectric environment of the nanoparticle, resulting in a spectral shift of the particle plasmon resonance. As we use single nanoparticles showing a homogeneous scattering spectrum, spectral shifts as small as 2 meV can be detected.
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