Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
Nano Letters2004Vol. 5(2), pp. 331–338
Citations Over TimeTop 1% of 2004 papers
Christian Kirchner, Tim Liedl, Stefan Kudera, Teresa Pellegrino, Almudena Muñoz Javier, Hermann E. Gaub, Sonja Stölzle, Niels Fertig, Wolfgang J. Parak
Abstract
Cytotoxicity of CdSe and CdSe/ZnS nanoparticles has been investigated for different surface modifications such as coating with mercaptopropionic acid, silanization, and polymer coating. For all cases, quantitative values for the onset of cytotoxic effects in serum-free culture media are given. These values are correlated with microscope images in which the uptake of the particles by the cells has been investigated. Our data suggest that in addition to the release of toxic Cd(2+) ions from the particles also their surface chemistry, in particular their stability toward aggregation, plays an important role for cytotoxic effects. Additional patch clamp experiments investigate effects of the particles on currents through ion channels.
Related Papers
- → SILANIZATION CHARACTERIZATION AND COMPOUND PROPERTIES OF SILICA-FILLED RUBBER CONTAINING A BLOCKED MERCAPTO SILANE(2016)18 cited
- → Influence of silane concentration on the silanization of multiwall carbon nanotubes(2013)61 cited
- → Optimization of the immobilization of bacterial spores on glass substrates with organosilanes(2016)4 cited
- Progress in Anti-corrosive Treatment of Metals by Silanization(2009)
- → Electrical Response of Silanization of Rubber Mixtures(2013)