Biological Behavior of Hat-Stacked Carbon Nanofibers in the Subcutaneous Tissue in Rats
Nano Letters2004Vol. 5(1), pp. 157–161
Citations Over TimeTop 10% of 2004 papers
Atsuro Yokoyama, Yoshinori Sato, Yoshinobu Nodasaka, Satoru Yamamoto, Takao Ḱawasaki, Masanobu Shindoh, Takao Kohgo, Tsukasa Akasaka, Motohiro Uo, Fumio Watari, Kazuyuki Tohji
Abstract
The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.
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