Optical and MRI Multifunctional Nanoprobe for Targeting Gliomas
Nano Letters2005Vol. 5(6), pp. 1003–1008
Citations Over TimeTop 1% of 2005 papers
Omid Veiseh, Conroy Sun, Jonathan Gunn, Nathan Kohler, Patrik Gabikian, Donghoon Lee, Narayan Bhattarai, Richard G. Ellenbogen, Raymond W. Sze, Andrew R. Hallahan, Jim Olson, Miqin Zhang
Abstract
A multifunctional nanoprobe capable of targeting glioma cells, detectable by both magnetic resonance imaging and fluorescence microscopy, was developed. The nanoprobe was synthesized by coating iron oxide nanoparticles with covalently bound bifunctional poly(ethylene glycol) (PEG) polymer, which were subsequently functionalized with chlorotoxin and the near-infrared fluorescing molecule Cy5.5. Both MR imaging and fluorescence microscopy showed significant preferential uptake of the nanoparticle conjugates by glioma cells. Such a nanoprobe could potentially be used to image resections of glioma brain tumors in real time and to correlate preoperative diagnostic images with intraoperative pathology at cellular-level resolution.
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